University of Alabama Research Advances Parkinson’s Treatment
Researchers at the University of Alabama, in collaboration with Oregon Health and Science University, have made significant strides in Parkinson’s disease treatment with a compound called Gardenin A. Previously tested in fruit flies, this flavonoid derived from a common South Asian shrub has demonstrated promising neuroprotective effects in mice.
The study, led by Dr. Lukasz Ciesla and researcher Dr. Urmila Maitra, aims to explore preventative therapies for Parkinson’s. Earlier research had observed that certain diets rich in flavonoids could lower the risk of neurodegenerative diseases, but the mechanisms behind these benefits were unclear. Building on previous findings, the team focused on Gardenin A, which had shown superior effects in fruit flies compared to other flavonoids.
In their recent study, the researchers utilized a genetic model to confirm the compound’s efficacy, revealing that Gardenin A not only alleviated cognitive and motor symptoms but also potentially improved memory in affected mice. This was particularly important, as both genetic and environmental factors contribute to Parkinson’s disease development.
Ciesla noted the significance of “gene-by-environment interaction,” wherein genetic predispositions influence disease susceptibility. Given the intertwined nature of these factors, any potential treatment must be broadly effective for varying patient profiles.
Importantly, the study identified that Gardenin A resolves neuroinflammation, distinguishing it from related compounds like Gardenin B, which lacked such effects. With the dual capability to address both cognitive and motor dysfunction, Gardenin A may pave the way for new therapies that harness the power of nature to tackle unmet medical needs in Parkinson’s treatment.
This research represents a pivotal moment in understanding and developing effective solutions for Parkinson’s disease.
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